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grapefruit juice-mediated inhibition of membrane transport proteins from the intestine to the blood, or inhibition of enzymes that activates a prodrug to an active metabolite leads to insufficient doses of the drug in the body resulting in loss of theurapeutic effect [27] Grapefruit or grapefruit juice can reduce the absorption of many drugs by ...
Gans suggests exploring some alternatives: "The nutrients found in grapefruit, such as vitamin A, C, and potassium, can easily be found in other fruits, such as cantaloupe, mango, papaya, berries ...
Grapefruit and grapefruit juice have been found to interact with numerous drugs, in many cases resulting in adverse effects. [4] This happens in two ways: one is that grapefruit can block an enzyme which metabolizes medication, [5] and if the drug is not metabolized, then the level of the drug in the blood can become too high, leading to an adverse effect. [5]
The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. The first published report on grapefruit drug interactions was in 1991 in the Lancet entitled "Interactions of Citrus Juices with Felodipine and Nifedipine", and was the first reported food-drug interaction clinically. The effects of grapefruit last ...
The most common adverse effects for losartan in adults are upper respiratory infections, dizziness, and back pain. [3] People with type 2 diabetes and kidney disease may experience diarrhea , fatigue, low blood pressure, low blood glucose, elevated potassium, chest pain, or allergic reaction . [ 3 ]
At about 92% water, grapefruit has one of the highest water contents of any fruit, so it can help with hydration. Opt for the heavier fruits as they contain more juice. Mariia Skovpen/istockphoto
A single glass of grapefruit juice can interfere with your body's ability to break down a medication. Here's how to protect your health.
Ingestion of naringin and related flavonoids can also affect the intestinal absorption of certain drugs, leading to either an increase or decrease in circulating drug levels. To avoid interference with drug absorption and metabolism, the consumption of citrus (especially grapefruit) and other juices with medications is advised against. [7]