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An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
Currently, the ICRP's definition of "equivalent dose" represents an average dose over an organ or tissue, and radiation weighting factors are used instead of quality factors. The phrase dose equivalent is only used for which use Q for calculation, and the following are defined as such by the ICRU and ICRP: ambient dose equivalent
Counts is the number of events detected, but dose rate relates to the amount of ionising energy deposited in the sensor of the radiation detector. The conversion calculation is dependent on the radiation energy levels, the type of radiation being detected and the radiometric characteristic of the detector. [1]
The International Committee for Weights and Measures states: "In order to avoid any risk of confusion between the absorbed dose D and the dose equivalent H, the special names for the respective units should be used, that is, the name gray should be used instead of joules per kilogram for the unit of absorbed dose D and the name sievert instead ...
In diagnostic radiology, the F-factor is the conversion factor between exposure to ionizing radiation and the absorbed dose from that radiation. In other words, it converts between the amount of ionization in air (roentgens or, in SI units, coulombs per kilogram of absorber material) and the absorbed dose in air (rads or grays).
D = Φ × conversion coefficient for absorbed dose. The driver for this is the need to measure the deterministic effect, which it is suggested, is more appropriate than stochastic effect. This would calculate equivalent dose quantities H lens and H skin. This would remove the need for the ICRU Sphere and the Q-L function.
The IC 50 of a drug can be determined by constructing a dose-response curve and examining the effect of different concentrations of antagonist on reversing agonist activity. IC 50 values can be calculated for a given antagonist by determining the concentration needed to inhibit half of the maximum biological response of the agonist. [ 4 ]
The deterministic effects that can lead to acute radiation syndrome only occur in the case of high doses (> ~10 rad or > 0.1 Gy) and high dose rates (> ~10 rad/h or > 0.1 Gy/h). A model of deterministic risk would require different weighting factors (not yet established) than are used in the calculation of equivalent and effective dose.