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The human immunodeficiency virus (HIV) [8] [9] [10] is a retrovirus [11] that attacks the immune system.It is a preventable disease. [5] It can be managed with treatment and become a manageable chronic health condition. [5]
AIDS denialists argue that AIDS does not exist or that AIDS is not caused by HIV; some of its proponents believe that AIDS is caused by lifestyle, including sexuality or drug use, and not by HIV. Both forms of AIDS denialism contradict scientific consensus. The evidence that HIV causes AIDS is generally considered conclusive among pathologists ...
The management of HIV/AIDS typically involves the use of multiple antiretroviral drugs. In many parts of the world, HIV has become a chronic condition, with progression to AIDS increasingly rare. HIV latency and the resulting viral reservoir in CD4 + T cells, dendritic cells, and macrophages is the main barrier to eradication of the virus. [19 ...
The spread of HIV/AIDS has affected millions of people worldwide; AIDS is considered a pandemic. [1] The World Health Organization (WHO) estimated that in 2016 there were 36.7 million people worldwide living with HIV/AIDS, with 1.8 million new HIV infections per year and 1 million deaths due to AIDS. [2]
HIV is commonly transmitted via unprotected sexual activity, blood transfusions, hypodermic needles, and from mother to child. Upon acquisition of the virus, the virus replicates inside and kills T helper cells , which are required for almost all adaptive immune responses .
HIV/AIDS can be transmitted sexually, via contaminated needles or blood transfusions, and from mother to child during pregnancy, birth or breast-feeding.
HIV-1 group M (responsible for the global pandemic) is estimated to have emerged in humans around 1920 near Kinshasa, then part of the Belgian Congo.This estimation was the result of time-scaled evolutionary models being applied to modern samples and retrieved early samples of HIV-1 (M).
Left untreated, the chronic stage can last between 10 and 15 years. However, some individuals can move through this stage quickly to the AIDS phase. [4] An untreated HIV infection ultimately progresses to AIDS (acquired immunodeficiency syndrome). In the AIDS phase, the CD4 T-cell count significantly drops to below 200 cells per cubic millimeter.