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Case reports have noted the absence of fever in serum sickness–like reactions to amoxicillin. Laboratory abnormalities include normal or mild decreases in serum C3, C4, and CH50 levels, and mild proteinuria. In contrast to true serum sickness, renal and hepatic involvement is rare.
Serum sickness in humans is a reaction to proteins in antiserum derived from a non-human animal source, occurring 5–10 days after exposure. Symptoms often include a rash , joint pain , fever , and lymphadenopathy .
A Jarisch–Herxheimer reaction is a sudden and typically transient reaction that may occur within 24 hours of being administered antibiotics for an infection by a spirochete, including syphilis, leptospirosis, Lyme disease, and relapsing fever. [1]
[45] [46] Second-line therapy should be considered for patients who have poor response to first-line treatment. Alternative choices include amoxicillin-clavulanate, nitrofurantoin, TMP/SMX, and ciprofloxacin. [44] For the treatment of simple cystitis in children, a five-day oral course of cephalexin is the preferred choice.
This mechanism is seen in serum sickness and is associated with systemic symptoms such as fever, joint pain, and neurological symptoms. [4] Some medications, like opioids and certain other drugs, induce urticaria by directly acting on mast cells, triggering histamine release. [2]
Vivian Health examines five trends that could redefine nurses' roles, enhance patient care, and alter the entire healthcare system in 2025 and beyond.
The symptoms of DRESS syndrome usually begin 2 to 6 weeks but uncommonly up to 8–16 weeks after exposure to an offending drug. Symptoms generally include fever, an often itchy rash which may be morbilliform or consist mainly of macules or plaques, facial edema (i.e. swelling, which is a hallmark of the disease), enlarged and sometimes painful lymph nodes, and other symptoms due to ...
Did this person take anti-psychiatric medication? Was this medication continued by jail staff, or was there a gap in treatment? Did the autopsy/toxicity report indicate this person was under the influence of drugs or alcohol? Was this person seen by a mental health professional? 5. Reporting on drug- and alcohol-related deaths