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For example, in clinical trials, the drug strontium ranelate was found to aid bone growth, increase bone density, and lessen vertebral, peripheral, and hip fractures in women. Strontium ranelate is an antiosteoporotic agent which both increases bone formation and reduces bone resorption, resulting in a rebalance of bone turnover in favor of ...
The mean strontium content of ocean water is 8 mg/L. [50] [51] At a concentration between 82 and 90 μmol/L of strontium, the concentration is considerably lower than the calcium concentration, which is normally between 9.6 and 11.6 mmol/L. [52] [53] It is nevertheless much higher than that of barium, 13 μg/L. [11]
To prevent low bone density it is recommended to have sufficient calcium and vitamin D. [17] [18] Sufficient calcium is defined as 1,000 mg per day, increasing to 1,200 mg for women above 50 and men above 70. [18] Sufficient vitamin D is defined as 600 IUs per day for adults 19 to 70, increasing to 800 IUs per day for those over 71. [18]
The USPSTF does not recommend low dose supplementation (less than 1 g of calcium and 400 IU of vitamin D) in postmenopausal women as there does not appear to be a difference in fracture risk. [129] A 2015 review found little data that supplementation of calcium decreases the risk of fractures. [ 130 ]
Maternal vitamin D deficiency can cause fetal bone defects from before birth and impairment of bone quality after birth. [81] [82] Rickets typically appear between 3 and 18 months of age. [83] This condition can be caused by vitamin D, calcium or phosphorus deficiency. [84]
Mapping of several bone diseases onto levels of vitamin D (calcidiol) in the blood [6] Normal bone vs. osteoporosis. Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body.
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