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A full set of sister chromatids is created during the synthesis (S) phase of interphase, when all the chromosomes in a cell are replicated. The two sister chromatids are separated from each other into two different cells during mitosis or during the second division of meiosis. Compare sister chromatids to homologous chromosomes, which are the ...
A: Short arm (p arm) B: Centromere C: Long arm (q arm) D: Sister Chromatids. In humans, centromere positions define the chromosomal karyotype, in which each chromosome has two arms, p (the shorter of the two) and q (the longer). The short arm 'p' is reportedly named for the French word "petit" meaning 'small'. [ 1 ]
The proteins encoded by these genes all function in the chromosome cohesion pathway that is employed in the cohesion of sister chromatids during mitosis, DNA repair, chromosome segregation and the regulation of developmental gene expression. Defects in these functions likely underlie many of the features of Cornelia de Lang Syndrome.
The Holliday junction is a key intermediate in homologous recombination, a biological process that increases genetic diversity by shifting genes between two chromosomes, as well as site-specific recombination events involving integrases. They are additionally involved in repair of double-strand breaks. [ 1 ]
The parABS system is a broadly conserved molecular mechanism for plasmid partitioning and chromosome segregation in bacteria.Originally identified as a genetic element required for faithful partitioning of low-copy-number plasmids, it consists of three components: the ParA ATPase, the ParB DNA-binding protein, and the cis-acting parS sequence.
Bar, 10 μm. Condensins are large protein complexes that play a central role in chromosome assembly and segregation during mitosis and meiosis (Figure 1). [ 1 ][ 2 ] Their subunits were originally identified as major components of mitotic chromosomes assembled in Xenopus egg extracts. [ 3 ]
The Boveri–Sutton chromosome theory (also known as the chromosome theory of inheritance or the Sutton–Boveri theory) is a fundamental unifying theory of genetics which identifies chromosomes as the carriers of genetic material. [1][2][3] It correctly explains the mechanism underlying the laws of Mendelian inheritance by identifying ...
Scheme showing cell cycle progression between prometaphase and anaphase. The spindle checkpoint, also known as the metaphase-to-anaphase transition, the spindle assembly checkpoint (SAC), the metaphase checkpoint, or the mitotic checkpoint, is a cell cycle checkpoint during metaphase of mitosis or meiosis that prevents the separation of the ...