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The dimerization and docking (D/D) domain of the regulatory subunit dimer of PKA binds with the A-kinase binding (AKB) domain (an amphipathic helix) of AKAP. The AKAPs also bind other components, including; phosphodiesterases ( PDEs ) which break down cAMP, phosphatases which dephosphorylate downstream PKA targets and also other kinases ( PKC ...
9495 238276 Ensembl ENSG00000179841 ENSMUSG00000021057 UniProt P24588 Q6PG46 D3YVF0 RefSeq (mRNA) NM_004857 NM_001101471 RefSeq (protein) NP_004848 NP_004848.3 NP_001094941 Location (UCSC) Chr 14: 64.47 – 64.47 Mb Chr 12: 76.37 – 76.38 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene. Function The A ...
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A-kinase anchor protein 4 is a scaffold protein that in humans is encoded by the AKAP4 gene. [5] [6] [7] It involves in the intracellular signalling of protein kinase -A. [8] AKAP4 is called as cancer /testis antigen (CTA), it belongs to a class of tumour linked antigens categories by high expression in germ cells and cancer than normal tissues. [9]
This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion . This protein is speculated to be involved in the cAMP -dependent signal transduction pathway and in directing RNA to a specific cellular compartment.
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n/a Ensembl ENSG00000127914 n/a UniProt Q99996 Q6PJH3 n/a RefSeq (mRNA) NM_005751 NM_147166 NM_147171 NM_147185 NM_001379277 n/a RefSeq (protein) NP_005742 NP_671714 NP_001366206 NP_005742.4 NP_671714.1 n/a Location (UCSC) Chr 7: 91.94 – 92.11 Mb n/a PubMed search n/a Wikidata View/Edit Human A-kinase anchor protein 9 is a protein that in humans is encoded by the AKAP9 gene. AKAP9 is also ...
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