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It is used in both therapeutic and reproductive cloning. In 1996, Dolly the sheep became famous for being the first successful case of the reproductive cloning of a mammal. [1] In January 2018, a team of scientists in Shanghai announced the successful cloning of two female crab-eating macaques (named Zhong Zhong and Hua Hua) from foetal nuclei. [2]
In 2005, they published again in Science the successful cloning of 11 person-specific stem cells using 185 human eggs. [6] The research was hailed as "a ground-breaking paper" in science. Hwang was elevated as "the pride of Korea", [ 7 ] "national hero" [of Korea], [ 8 ] and a "supreme scientist", [ 9 ] to international praise and fame.
Therapeutic cloning would involve cloning cells from a human for use in medicine and transplants. It is an active area of research, and is in medical practice over the world. Two common methods of therapeutic cloning that are being researched are somatic-cell nuclear transfer and (more recently) pluripotent stem cell induction .
Nuclear transfer is a delicate process that is a major hurdle in the development of cloning technology. [5] Materials used in this procedure are a microscope, a holding pipette (small vacuum) to keep the oocyte in place, and a micropipette (hair-thin needle) capable of extracting the nucleus of a cell using a vacuum.
Reproductive Sciences Medical Center; Stemagen Corporation; Development of Human cloned Blastocyst Following Somatic Cell Nuclear Transfer (SCNT) with Adult Fibroblasts by Andrew J. French, Cathrine A. Adams, Linda S. Anderson, John R. Kitchen, Marcus R. Hughes and Samuel H. Wood. Published in the online journal Stem Cells published by AlphaMed Press January 17, 2008.
Therapeutic cloning would involve cloning cells from a human for use in medicine and transplants, and is an active area of research, but is not in medical practice anywhere in the world, as of 2024. Two common methods of therapeutic cloning that are being researched are somatic-cell nuclear transfer and, more recently, pluripotent stem cell ...
The first therapeutic use of gene transfer as well as the first direct insertion of human DNA into the nuclear genome was performed by French Anderson in a trial starting in September 1990. Between 1989 and December 2018, over 2,900 clinical trials were conducted, with more than half of them in phase I . [ 5 ]
Their collaboration led to a major announcement in 2004, claiming the successful cloning of human embryos, with the potential to cure some diseases. The announcement fueled a heated debate on bioethics, despite Hwang and Moon emphasizing that their work focused solely on therapeutic purposes and strongly opposing reproductive cloning." [1]