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4-AcO-DMT is a prodrug of psilocin (4-HO-DMT). [2] As a prodrug of psilocin, 4-AcO-DMT acts as a non-selective agonist of serotonin receptors , including of the serotonin 5-HT 2A receptor . [ 1 ] The psychedelic effects of 4-AcO-DMT are mediated specifically by activation of the serotonin 5-HT 2A receptor.
Beans: 5-MeO-DMT. Up to 12.4% bufotenin. [33] DMT Psychedelic + depressant Between 2013 and 2017, archaeological excavations at the Quilcapampa site in southern Peru, found that the Wari used seeds from the vilca tree and combined the hallucinogenic drug with chicha, or beer made from the molle tree. [117] Psilocybin mushroom + cocoa [dubious ...
4-HO-5-MeO-DMT (psilomethoxin) mushrooms derived from Psilocybe cubensis mycelium in substrate with added 5-MeO-DMT. [1] [2] 4-HO-DET and 4-PO-DET mushrooms derived from Psilocybe cubensis mycelium in substrate with added DET. [3] [4] 4-HO-DiPT mushrooms derived from Psilocybe cubensis mycelium in substrate with added DiPT. [2] 4-HO-DPT ...
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[12] [13] [14] [2] Both psilocybin and 4-AcO-DMT are prodrugs of the serotonergic psychedelic psilocin. [1] [15] [2] [11] Psychedelic mushroom stores operate in a legal grey area and the products sold by these stores may be either illegal controlled substances (e.g., psilocybin mushrooms, psilocybin) or legal (e.g., Amanita muscaria mushrooms ...
O-Acetylbufotenine, or bufotenine O-acetate, also known as 5-acetoxy-N,N-dimethyltryptamine (5-AcO-DMT) or O-acetyl-N,N-dimethylserotonin, is a synthetic tryptamine derivative and putative serotonergic psychedelic.
In rodents, 4-HO-TMT showed no head-twitch response (a behavioral proxy of psychedelic effects), hypolocomotion, or hypothermia, in contrast to psilocin and norpsilocin, but similarly to aeruginascin. [3] A synthetic prodrug of 4-HO-TMT, 4-AcO-TMT, has been developed. [1] [5] It is analogous to psilacetin (4-AcO-DMT), a prodrug of psilocin. [1] [5]
As with DMT, CYB004 is a potent agonist of the serotonin 5-HT 2A receptor and produces psychedelic-like effects in animals. [ 1 ] [ 6 ] [ 3 ] However, CYB004, due to its deuteration, is more resistant to metabolism than DMT and shows a longer elimination half-life (by 2.5- to 2.9-fold) and slower clearance (by 38 to 55%) in animals. [ 3 ]