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SGLT2 is the major cotransporter involved in glucose reabsorption in the kidney. [6] SGLT2 is located in the early proximal tubule, and is responsible for reabsorption of 80-90% of the glucose filtered by the kidney glomerulus. [7] Most of the remaining glucose absorption is by sodium/glucose cotransporter 1 (SGLT1) in more distal sections of ...
SGLT2 inhibitors (also called gliflozins or flozins) are a class of medications that inhibit sodium-glucose transport proteins in the nephron (the functional units of the kidney), unlike SGLT1 inhibitors that perform a similar function in the intestinal mucosa. The foremost metabolic effect of this is to inhibit reabsorption of glucose in the ...
For an example there was a big difference if there was an n-pentyl group (IC 50 = 13,3 nM), n-butyl (IC 50 = 119 nM), phenyl with 2-furyl (IC 50 = 0,720) or 3-thiophenyl (IC 50 = 0,772). As seen in table 1, the in vitro activity increases depending on what compound is bonded to the distal ring (given that in the C-4 region of the proximal ...
The American Stroke Association just released new stroke prevention guidelines. They include considering GLP-1 receptor agonists. Doctors applaud the new guidance. More than 795,000 people in the ...
Additionally, women over 50 are at higher risk for osteoporosis and bone density loss, and vitamin D can help mitigate this risk, he says. With this in mind, he recommends the vitamin D3 softgel ...
Empagliflozin is an inhibitor of the sodium glucose co-transporter-2 (SGLT-2), and works by increasing sugar loss in urine. [2] Empagliflozin was approved for medical use in the United States and in the European Union in 2014. [13][23][24] It is on the World Health Organization's List of Essential Medicines. [25]
Research suggests that exercising improves cognitive processes and memory, while increasing the thickness of your cerebral cortex, which is responsible for tasks like language, thinking, and ...
Aging of the brain is a process of transformation of the brain in older age, including changes all individuals experience and those of illness (including unrecognised illness). Usually this refers to humans. Since life extension is only pertinent if accompanied by health span extension, and, more importantly, by preserving brain health and ...