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Pethidine is the most widely used opioid in labour and delivery. [16] It has fallen out of favour in some countries, such as the United States, in favour of other opioids, due to its potential drug interactions, especially with serotonergics, and its neurotoxic metabolite, norpethidine. [10]
Metabolism of pethidine to pethidinic acid is carried out mainly by the carboxylesterase enzyme hCE-1 in the liver, [5] and since the activity of this enzyme can vary between individuals, the rate and extent of pethidinic acid production can vary. [6] [7] Frank Wätjen used pethidinic acid as a precursor chemical to a heterocyclic moiety. [8]
Bioaccumulation of norpethidine is a major complication when pethidine is used in medicine as an analgesic, as when pethidine is used in high doses [5] or administered by intravenous infusion, [6] norpethidine can accumulate in the body at a faster rate than it is being excreted, particularly in elderly patients [7] or those with compromised ...
Day 2: Soil as Medicine: The Role of Regenerative Organic Agriculture in Food as Medicine. Day 3: Investing in Life-Long Health: Equitable, Accessible, and Community-Centered Food as Medicine.
The Passaic Agricultural Chemical Works in Newark, New Jersey, 1876. An agrochemical or agrichemical, a contraction of agricultural chemical, is a chemical product used in industrial agriculture. Agrichemical typically refers to biocides (pesticides including insecticides, herbicides, fungicides and nematicides) alongside synthetic fertilizers.
Hydroxypethidine (Bemidone) is an opioid analgesic that is an analogue of the more commonly used pethidine (meperidine). Hydroxypethidine is slightly more potent than meperidine as an analgesic, 1.5x meperidine in potency, [2] and it also has NMDA antagonist properties like its close relative ketobemidone.
Berries are the perfect addition to any smoothie and yogurt bowl—plus, they're perfect for snacking. But they also can come with a real risk of foodborne illnesses. The U.S. Food and Drug ...
Agricultural chemistry is the chemistry, especially organic chemistry and biochemistry, as they relate to agriculture. Agricultural chemistry embraces the structures and chemical reactions relevant in the production, protection, and use of crops and livestock .