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A blue circle, the symbol for diabetes. High blood sugar levels, autoantibodies targeting insulin-producing cells. Type 1 diabetes ( T1D ), formerly known as juvenile diabetes, is an autoimmune disease that originates when cells that make insulin (beta cells) are destroyed by the immune system. [ 5] Insulin is a hormone required for the cells ...
392 million (2015) [ 11] Type 2 diabetes ( T2D ), formerly known as adult-onset diabetes, is a form of diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. [ 6] Common symptoms include increased thirst, frequent urination, fatigue and unexplained weight loss. [ 3]
The condition known today as diabetes (usually referring to diabetes mellitus) is thought to have been described in the Ebers Papyrus ( c. 1550 BC ). Ayurvedic physicians (5th/6th century BC) first noted the sweet taste of diabetic urine, and called the condition madhumeha ("honey urine"). The term diabetes traces back to Demetrius of Apamea ...
4.2 million (2019) [ 9] Diabetes mellitus, often known simply as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. [ 10][ 11] Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body becoming unresponsive to the hormone's effects. [ 12]
Elliott P. Joslin. Elliott Proctor Joslin (June 6, 1869 – January 28, 1962) was the first medical doctor in the United States to specialize in diabetes and was the founder of the present-day Joslin Diabetes Center in Boston, Massachusetts. Joslin was involved for seven decades in most aspects of diabetes investigation and treatment, save for ...
In the DCCT (Diabetes Control and Complications Trial, 1995) study, the annual incidence of neuropathy was 2% per year but dropped to 0.56% with intensive treatment of Type 1 diabetics. The progression of neuropathy is dependent on the degree of glycemic control in both Type 1 and Type 2 diabetes.
The term double diabetes refers to when somebody has type 1 diabetes and clinical features for insulin resistance or family history of type 2 diabetes. It is also called mixed-type diabetes or hybrid diabetes. Many but not all people with double diabetes are obese or overweight.
The insulin transduction pathway is a biochemical pathway by which insulin increases the uptake of glucose into fat and muscle cells and reduces the synthesis of glucose in the liver and hence is involved in maintaining glucose homeostasis. This pathway is also influenced by fed versus fasting states, stress levels, and a variety of other hormones.