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Constipation caused by certain opioid (narcotic) pain medications in people with chronic (ongoing), noncancer pain, [9] or in patients with long-lasting pain caused by a previous cancer or its treatment who do not need weekly increases in opioid dosage. [4] [10] [12] [13] The effectiveness of lubiprostone has not been established in patients ...
Prucalopride is contraindicated where there is hypersensitivity to the active substance or to any of the excipients, renal impairment requiring dialysis, intestinal perforation or obstruction due to structural or functional disorder of the gut wall, obstructive ileus, severe inflammatory conditions of the intestinal tract, such as Crohn's disease, and ulcerative colitis and toxic megacolon ...
Lactulose is a non-absorbable sugar used in the treatment of constipation and hepatic encephalopathy. [3] [4] It is administered orally for constipation, and either orally or rectally for hepatic encephalopathy. [3] It generally begins working after 8–12 hours, but may take up to 2 days to improve constipation. [1] [2]
Eperisone hydrochloride is available as the brand name preparations Myonal and Epry as 50 mg sugar-coated tablets, or as 10% granules for oral administration. [6] An experimental form of the drug, as a transdermal patch system, has shown promising results in laboratory tests on rodents; however, this product is not currently available for human use.
A prescribing cascade occurs when a person is prescribed a drug and experiences an adverse drug effect that is misinterpreted as a new medical condition, so the patient is prescribed another drug. [21] Polypharmacy also increases the burden of medication taking particularly in older people and is associated with medication non-adherence. [22]
Secondary constipation, which is due to another cause, such as chronic conditions, like Type 2 diabetes, poor dietary choices or neurological conditions that may impact intestinal motility
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