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Each nonribosomal peptide synthetase can synthesize only one type of peptide. Nonribosomal peptides often have cyclic and/or branched structures, can contain non- proteinogenic amino acids including D -amino acids, carry modifications like N -methyl and N -formyl groups, or are glycosylated , acylated , halogenated , or hydroxylated .
The nonribosomal peptide synthetase (NRPS), a multi-modular enzyme complex, minimally contains repeating, tri-domains (adenylation (A), peptidyl carrier protein (PCP) and lastly condensation(C)). The adenylation domain (A) is the focus for substrate specificity since it is the initiating and substrate recognition domain.
The three main classes of fungal secondary metabolites are: polyketides, nonribosomal peptides and terpenes. Although fungal secondary metabolites are not required for growth they play an essential role in survival of fungi in their ecological niche. [33] The most known fungal secondary metabolite is penicillin discovered by Alexander Fleming ...
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NAD supplements are the latest health trend to explode on TikTok, where people claim the supplements can help boost metabolism, improve cognition, and slow or even reverse aging.
Berberine, a plant compound traditionally used in herbal medicine, is today commonly stocked on the shelves of health food stores and pharmacies as a supplement.. Berberine supplements gained ...
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