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Vitamin B 1 analogues are analogues of vitamin B 1, thiamine. They typically have improved bioavailability relative to thiamine itself, and are used to treat conditions caused by vitamin B 1 deficiency. These conditions include beriberi, Korsakoff's syndrome, Wernicke's encephalopathy and diabetic neuropathy.
Benfotiamine (rINN, or S-benzoylthiamine O-monophosphate) is a synthetic, fat-soluble, S-acyl derivative of thiamine (vitamin B1) that is approved in some countries as a medication or dietary supplement to treat diabetic sensorimotor polyneuropathy. Benfotiamine was developed in late 1950s in Japan. [1] [2]
Thiamine, also known as thiamin and vitamin B 1, is a vitamin – an essential micronutrient for humans and animals. [1] [3] [4] It is found in food and commercially synthesized to be a dietary supplement or medication. [1] Phosphorylated forms of thiamine are required for some metabolic reactions, including the breakdown of glucose and amino ...
Vitamin Name Deficiency effects Vitamin B 1: Thiamine: Thiamine deficiency causes beriberi. Symptoms of this disease of the nervous system include weight loss, emotional disturbances, Wernicke encephalopathy (impaired sensory perception), weakness and pain in the limbs, periods of irregular heartbeat, and edema (swelling of bodily tissues).
Sulbutiamine sold under the brand names Arcalion, Enerion, and Sulbuxin is a synthetic derivative of thiamine (vitamin B 1). In France, it is used to treat symptoms of weakness or fatigue . In Uruguay , it is prescribed when there is thiamine deficiency, mainly in patients with asthenia , overwork, apathy , depressive states, memory disorders ...
Thiamine deficiency is a medical condition of low levels of thiamine (vitamin B 1). [1] A severe and chronic form is known as beriberi. [1] [7] The name beriberi was possibly borrowed in the 18th century from the Sinhalese phrase බැරි බැරි (bæri bæri, “I cannot, I cannot”), owing to the weakness caused by the condition.
Thiamine pyrophosphate is a cofactor that is present in all living systems, in which it catalyzes several biochemical reactions. Thiamine pyrophosphate is synthesized in the cytosol and is required in the cytosol for the activity of transketolase and in the mitochondria for the activity of pyruvate-, oxoglutarate- and branched chain keto acid ...
In patients suspected of WE, thiamine treatment should be started immediately. [39] Blood should be immediately taken to test for thiamine, other vitamins and minerals levels. Following this an immediate intravenous or intramuscular dose of thiamine should be administered [36] two or three times daily. Thiamine administration is usually ...
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