Search results
Results from the WOW.Com Content Network
Phospholipase C cleaving PIP2 into IP3 and DAG. Specific signals can trigger a sudden increase in the cytoplasmic Ca 2+ levels to 500–1,000 nM by opening channels in the ER or the plasma membrane. The most common signaling pathway that increases cytoplasmic calcium concentration is the phospholipase C (PLC) pathway.
Inositol trisphosphate or inositol 1,4,5-trisphosphate abbreviated InsP 3 or Ins3P or IP 3 is an inositol phosphate signaling molecule. It is made by hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP 2), a phospholipid that is located in the plasma membrane, by phospholipase C (PLC).
Inositol trisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca 2+ channel activated by inositol trisphosphate (InsP3). InsP3R is very diverse among organisms, and is necessary for the control of cellular and physiological processes including cell division, cell proliferation, apoptosis, fertilization, development, behavior, learning and memory. [2]
inositol-phospholipid signaling pathway. The inositol-phospholipid signaling pathway is responsible for the generation of IP3 through the cleavage of Phosphatidylinositol 4,5-bisphosphate (PIP2) found in the lipid bi-layer of the plasma membrane by phospholipase C in response to either receptor tyrosine kinase or Gq alpha subunit-G protein-coupled receptor signaling.
IP3 is a secondary messenger that helps to send neuronal signals through the body. The neuronal cells have the calcium-signaling microdomains in the cytoplasm right next to the pre- and post-synaptic calcium channels in the nerve cells. Figure 1 is an example of how Na-K-ATPase forms the calcium-signaling microdomain.
In biology, the enzyme ITP3K is abbreviated a number of different ways, including 1D-myo-inositol-trisphosphate 3-kinase, ITP3K, ITPK, IP3-kinase, IP3-3-kinase, Ins(1,4,5)P3 3-kinase. In addition the enzyme may be named as the product of one of 3 genes in humans ITPKA , ITPKB , and ITPKC , or one of two in fruit flies, IP3K1 and IP3K2 —a ...
The hydrolytic products also go on to modulate the activity of downstream proteins important for cellular signaling. IP3 is soluble, and diffuses through the cytoplasm and interacts with IP3 receptors on the endoplasmic reticulum, causing the release of calcium and raising the level of intracellular calcium.
In this pathway, IMPase is the common, final step in recycling IP3 to produce PIP 2. IMPase does this by dephosphorylating inositol monophosphate to produce inorganic phosphate and myo-inositol, the precursor to PIP2. Because of IMPase's crucial role in this signaling pathway, it is a potential drug target for inhibition and modulation. [11]