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H&E stain. Fibrin (also called Factor Ia) is a fibrous, non-globular protein involved in the clotting of blood. It is formed by the action of the protease thrombin on fibrinogen, which causes it to polymerize. The polymerized fibrin, together with platelets, forms a hemostatic plug or clot over a wound site. When the lining of a blood vessel is ...
In the conversion of fibrinogen into fibrin, thrombin catalyzes the cleavage of fibrinopeptides A and B from the respective Aα and Bβ chains of fibrinogen to form fibrin monomers. [13] Factor XIIIa is a transglutaminase that catalyzes the formation of covalent bonds between lysine and glutamine residues in fibrin. The covalent bonds increase ...
A protein contact map represents the distance between all possible amino acid residue pairs of a three-dimensional protein structure using a binary two-dimensional matrix. For two residues and , the element of the matrix is 1 if the two residues are closer than a predetermined threshold, and 0 otherwise. Various contact definitions have been ...
RaptorX. remote homology detection, protein 3D modeling, binding site prediction. Automated webserver and Downloadable program. Biskit. wraps external programs into automated workflow. BLAST search, T-Coffee alignment, and MODELLER construction. ESyPred3D. Template detection, alignment, 3D modeling. Automated webserver.
The creation of UML was originally motivated by the desire to standardize the disparate notational systems and approaches to software design. It was developed at Rational Software in 1994–1995, with further development led by them through 1996. [2] In 1997, UML was adopted as a standard by the Object Management Group (OMG) and has been ...
The design should "minimize the intellectual distance" between the software and the problem as it exists in the real world. That is, the structure of the software design should, whenever possible, mimic the structure of the problem domain. The design should exhibit uniformity and integration. A design is uniform if it appears fully coherent.
In software engineering, a design pattern describes a relatively small, well-defined aspect (i.e. functionality) of a computer program in terms of how to write the code. Using a pattern is intended to leverage an existing concept rather than re-inventing it. This can decrease the time to develop software and increase the quality of the ...
A functional specification (also, functional spec, specs, functional specifications document (FSD), functional requirements specification) in systems engineering and software development is a document that specifies the functions that a system or component must perform (often part of a requirements specification) (ISO/IEC/IEEE 24765-2010). [1]