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  2. Synthetic cannabinoids - Wikipedia

    en.wikipedia.org/wiki/Synthetic_cannabinoids

    Bag and contents of a well-known early brand of synthetic cannabinoids named Spice that contains herbs covered with synthetic cannabinoids, now illegal throughout much of the world. Synthetic cannabinoids are a class of designer drug molecules that bind to the same receptors to which cannabinoids (THC, CBD and many others) in cannabis plants ...

  3. Melange (fictional drug) - Wikipedia

    en.wikipedia.org/wiki/Melange_(fictional_drug)

    Melange (/ m eɪ ˈ l ɑː n ʒ / [1]), often referred to as "the spice", is the fictional psychedelic drug central to the Dune series of science fiction novels by Frank Herbert and derivative works. In the series, the most essential and valuable commodity in the universe is melange, a drug that gives the user a longer life span, greater ...

  4. Synthetic drug - Wikipedia

    en.wikipedia.org/wiki/Synthetic_drug

    "Spice", the brand name given to synthetic cannabinoids. There are seven major structural groups, which are naphthoylindoles , naphthylmethylindoles , naphthoypyrroles, naphthylmethylindenes , phenylacetylindoles , cyclohexylphenols and classical cannabinoids respectively. [ 3 ]

  5. John W. Huffman - Wikipedia

    en.wikipedia.org/wiki/John_W._Huffman

    In the late 2000s, two of Huffman's cannabinoid compounds were found in street drugs K2 and Spice being sold in Germany as marijuana alternatives. "I figured once it got started in Germany it was going to spread. I'm concerned that it could hurt people," Huffman said. "I think this was something that was more or less inevitable.

  6. Recreational drug use - Wikipedia

    en.wikipedia.org/wiki/Recreational_drug_use

    Recreational drug use is the use of one or more psychoactive drugs to induce an altered state of consciousness, ... Synthetic cannabis: "Spice", "K2", JWH-018, AM-2201;

  7. JWH-018 - Wikipedia

    en.wikipedia.org/wiki/JWH-018

    JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]

  8. MDMB-4en-PINACA - Wikipedia

    en.wikipedia.org/wiki/MDMB-4en-PINACA

    In 2021, MDMB-4en-PINACA was the most common synthetic cannabinoid identified by the Drug Enforcement Administration in the United States. [10] MDMB-4en-PINACA differs from 5F-MDMB-PINACA due to replacement of 5-fluoropentyl with a pent-4-ene moiety (4-en).

  9. AB-PINACA - Wikipedia

    en.wikipedia.org/wiki/AB-PINACA

    AB-PINACA is a compound that was first identified as a component of synthetic cannabis products in Japan in 2012. [2]It was originally developed by Pfizer in 2009 as an analgesic medication.