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A 2006 study of 124 premenopausal women measured sex hormone-binding globulin (SHBG), including before and after discontinuation of the oral contraceptive pill. Women continuing use of oral contraceptives had SHBG levels four times higher than those who never used it, and levels remained elevated even in the group that had discontinued its use.
Between 2015 and 2017, 64.9% of women ages 15–49 in the United States were using contraception, and of those 12.6% were using the oral contraceptive pill. [46] There are approximately 100 million users of combined oral contraceptives worldwide, with use being more common in Western Europe, Northern Europe, and the United States. [47]
Two types of female oral contraceptive pill, taken once per day, are widely available: The combined oral contraceptive pill contains estrogen and a progestin; colloquially known as "the Pill". The progestogen-only pill, colloquially known as "minipill". For perfect use the pill is 99% effective and typical use is 91% effective.
For example, a failure rate of 20% means that 20 of 100 women become pregnant during the first year of use. Note that the rate may go above 100% if all women, on average, become pregnant within less than a year. In the degenerated case of all women becoming pregnant instantly, the rate would be infinite.
Use of oral contraceptive can impair muscle gains in young women. [21] The metabolic impact of oral contraceptives are significant and contraceptive pills can increase the risk of heart attacks. Many preclinical and clinical studies reveal that changes in lipoprotein metabolism are a major contributing factor to atherosclerosis. [22]
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Progestogen-only pills (POPs), colloquially known as "mini pills", are a type of oral contraceptive that contain synthetic progestogens and do not contain estrogens. [4] They are primarily used for the prevention of undesired pregnancy, although additional medical uses also exist.
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