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Of the estimated 16 million "long term" (over 24 months) users, roughly 70 percent are female. [299] As of 2017, about 16.5% of white people in the United States took antidepressants compared with 5.6% of black people in the United States. [300] Structural formula of the SSRI sertraline
They publish WebMD the Magazine, a patient-directed publication distributed bimonthly free of charge to 85 percent of physician waiting rooms. [13] Medscape is a professional portal for physicians and has training materials, a drug database, and clinical information on 30 medical specialty areas and more than 30 physician discussion boards. [14]
Finasteride is also used to treat male pattern baldness (androgenic alopecia) in men, a condition that develops in up to 80% of Caucasian men aged 70 and over. [ 24 ] [ 4 ] In the United States, finasteride and minoxidil are the only two FDA approved drugs for the treatment of male pattern hair loss as of 2017. [ 25 ]
It is conjugated in the kidney for excretion in the urine, where 75% of the drug is excreted, [116] and about 15% is eliminated in feces. [117]: 430 Desmethylmirtazapine is an active metabolite of mirtazapine which is believed to contribute about 3-10% to the drugs overall effects and has a half-life of about 25 hours. [8]
The evidence overall supports the effectiveness of bupropion over placebo for the treatment of depression. [ 41 ] [ 18 ] [ 42 ] Some peer-reviewed studies suggest the quality of evidence is low. [ 42 ] [ 18 ] Some meta-analyses report that bupropion has an at-most small effect size for depression.
Sertraline, sold under the brand name Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. [10] The effectiveness of sertraline for depression is similar to that of other antidepressants, and the differences are mostly confined to side effects.
Atomoxetine is sometimes used in the treatment of cognitive impairment and frontal lobe symptoms due to conditions like traumatic brain injury (TBI). [47] [48] It is used with the goal of treating ADHD-like symptoms such as sustained attentional problems, disinhibition, [49] lack of arousal, fatigue, and depression, including symptoms from cognitive disengagement syndrome. [47]
Lamotrigine has fewer drug interactions than many anticonvulsant drugs, although pharmacokinetic interactions with carbamazepine, phenytoin and other hepatic enzyme inducing medications may shorten half-life. [83] Dose adjustments should be made on clinical response, but monitoring may be of benefit in assessing compliance. [5]