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Phentermine is used for a short period of time to promote weight loss, if exercise and calorie reduction are not sufficient, and in addition to exercise and calorie reduction. [5] [11] Phentermine is approved for up to 12 weeks of use and most weight loss occurs in the first weeks. [11]
Phentermine and topiramate can cause fetal harm. Data from pregnancy registries and epidemiology studies indicate that a fetus exposed to topiramate in the first trimester of pregnancy has an increased risk of oral clefts (cleft lip with or without cleft palate). [3]
Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4]
"Comparison of frovatriptan plus dexketoprofen (25 mg or 37.5 mg) with frovatriptan alone in the treatment of migraine attacks with or without aura: a randomized study". Cephalalgia. 34 (6): 434–445. doi: 10.1177/0333102413515342. PMID 24363238
While there is a lack of randomized controlled trials evaluating the use of triamterene in the treatment of Ménière's disease, the typical treatment is 37.5 mg of triamterene with 25 mg of hydrochlorothiazide 1–2 capsules daily. [25] [26] This recommendation was given a Strength of Recommendation Taxonomy (SORT) grade of C. [citation needed]
[19] [20] [21] Across all administered dose levels (25 mg/m 2 for the i.m. route of administration and 37.5 mg/m 2 for the i.v. route), JZP-458 exhibited favorable tolerability without any unexpected adverse events (AEs), serious AEs, or AEs of grade 3 or higher. Among the treatment-emergent AEs reported, nausea was the most frequently observed ...
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