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The signs, symptoms and cognitive profile of PDD are similar to those of DLB; [2] DLB and PDD are clinically similar after dementia occurs in Parkinson's disease. [5] Parkinson's disease is a risk factor for PDD; it speeds up decline in cognition leading to PDD. [2] Up to 78% of people with PD have dementia. [2]
[12] [13] The Lewy body dementias—dementia with Lewy bodies (DLB), and Parkinson's disease dementia (PDD)—are distinguished by the timing when cognitive and motor symptoms appear. [14] The two Lewy body dementias are often considered to belong on a spectrum of Lewy body disease that includes Parkinson's disease. [2] [5]
The DNA repair function of alpha-synuclein appears to be compromised in Lewy body inclusion bearing neurons, and this may trigger cell death. Study of synucleinopathy mouse models of Parkinson's disease indicates that alpha-synuclein pathogenesis is associated with increased DNA damage and activation of the DNA damage response. [19]
Veronica Brown lived with chronic fatigue, depression, and anxiety for over 10 years before she learned they were early signs of Parkinson's disease. Here's how she found relief after diagnosis.
“In general, the etiology of dementia in Parkinson’s is thought to be a mix of Lewy body pathology primarily, but, also to varying extents, Alzheimer’s disease pathology and vascular disease ...
Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease, mainly of the central nervous system, that affects both the motor and non-motor systems of the body. The symptoms usually emerge slowly, and, as the disease progresses, non-motor symptoms become more common.
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