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Tamsulosin is a selective α 1 receptor antagonist that has preferential selectivity for the α 1A receptor in the prostate versus the α 1B receptor in the blood vessels. [ 25 ] When alpha 1 receptors in the bladder neck, prostate, ureter, and urethra are blocked, a relaxation in smooth muscle tissue results. [ 16 ]
It is a combination of two previously existing medications: dutasteride, brand name Avodart, and tamsulosin, brand name Flomax. It contains 0.5 mg of dutasteride and 0.4 mg of tamsulosin hydrochloride. [2] Jalyn was the result of the CombAT (Combination of Avodart and Tamsulosin) trial of 2008.
Terazosin was the first long-lasting alpha 1 blocker approved by FDA to treat BPH. Doxazosin and Tamsulosin were approved after. The first-line treatment choice today to treat BPH is tamsulosin. It is not better tolerated, nor does it have greater efficacy than the previous drugs, however, it requires minimal dose titration in comparison.
Image credits: National Geographic #5. The 'Spanish Flu' actually likely got its start in Kansas, USA. It's only called the Spanish Flu because most countries involved in WWI had a near-universal ...
The Dr. Jose N. Rodriguez Memorial Hospital (DJNRMH), formerly known as Central Luzon Sanitarium, [1] and also called as the Tala Leprosarium, [2] was established in 1940, to accommodate patients with Hansen's Disease in the entire Luzon region in the Philippines.
Philippines Historical Committee marker installed in 1952. The San Lazaro Hospital was established in 1577 during the Spanish colonial period as a dispensary clinic in Intramuros by Fr. Juan Clemente, a Spanish priest. In 1578, it became a hospital which catered from patients afflicted with leprosy and other diseases. [2]
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage).
In February 2021, COVID-19 vaccines reached the Philippines and began to the administered. The Department of Health was criticized in a 2021 study saying that the Philippines was 2nd to the last in the world in terms by how effective the Philippine government did respond to the pandemic . [ 7 ]