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It is used as a precursor in the industrial synthesis of doxycycline hyclate. [ citation needed ] It has been found to act as an agonist of the human pregnane X receptor ligand-binding domain and to induce CYP3A4 expression in vitro .
Partial exceptions to these rules occur for doxycycline and minocycline, which may be taken with food (though not iron, antacids, or calcium supplements). Minocycline can be taken with dairy products because it does not chelate calcium as readily, although dairy products do decrease absorption of minocycline slightly. [39]
A hyclate (Latin: hyclas) is a pharmaceutical term for hydrochloride hemiethanolate hemihydrate [1] [2] (·HCl· 1 / 2 EtOH· 1 / 2 H 2 O), e.g. doxycycline hyclate. [ 3 ] [ 4 ] References
Generic 100 mg doxycycline capsules A package of generic doxycycline. In addition to the general indications for all members of the tetracycline antibiotics group, doxycycline is frequently used to treat Lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease, [13] [14] severe acne, rosacea, [15] [16] [17] and rickettsial infections. [18]
Here are links to possibly useful sources of information about Doxycycline. PubMed provides review articles from the past five years (limit to free review articles ) The TRIP database provides clinical publications about evidence-based medicine .
Zero tolerance testing is not testing down to "zero" molecules, which no chemist can accomplish, but rather testing to the limit of detection (LOD) of the best available technology. In other words, "zero tolerance" refers to the racing regulators' philosophy in regulating drug use in race horses—even trace amounts of drugs are not tolerated. [20]
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Chronic: The horse tires easily and is unsuitable for work. The horse may have a recurrent fever and anemia, and may relapse to the subacute or acute form even several years after the original attack. [citation needed] A horse may also not appear to have any symptoms, yet still tests positive for EIA antibodies.