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Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells. Though temsirolimus shows activity on its own, it is also known to be converted to sirolimus (rapamycin) in vivo; [4] therefore, its activity may be more attributed to its metabolite rather than the prodrug itself (despite claims to the ...
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Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa).
The trunk of the body contains, from superior to inferior, the thoracic region encompassing the chest [1] the mammary region encompassing each breast; the sternal region encompassing the sternum; the abdominal region encompassing the stomach area; the umbilical region is located around the navel; the coxal region encompassing the lateral (side ...
Pemigatinib, sold under the brand name Pemazyre, is an anti-cancer medication used for the treatment of bile duct cancer (cholangiocarcinoma). [5] [6] [8] [9] Pemigatinib works by blocking FGFR2 in tumor cells to prevent them from growing and spreading.
The axilla (pl.: axillae or axillas; also known as the armpit, underarm or oxter) is the area on the human body directly under the shoulder joint.It includes the axillary space, an anatomical space within the shoulder girdle between the arm and the thoracic cage, bounded superiorly by the imaginary plane between the superior borders of the first rib, clavicle and scapula (above which are ...
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. [1]
The torso or trunk is an anatomical term for the central part, or the core, of the body of many animals (including human beings), from which the head, neck, limbs, tail and other appendages extend.