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The bladder wall muscle overactivity results in sporadic bladder muscle contraction, which increases pressure in the bladder and decreases the volume of urine the bladder can hold. [2] If NDO is not treated, increased pressure in the bladder can put the upper urinary tract at risk of harm, including possible permanent damage to the kidneys. [ 2 ]
Chronic urinary retention that is due to bladder blockage which can either be as a result of muscle damage or neurological damage. [7] If the retention is due to neurological damage, there is a disconnect between the brain to muscle communication, which can make it impossible to completely empty the bladder. [7]
The bladder also contains β 3 adrenergic receptors, and pharmacological agonists of this receptor are used to treat overactive bladder. The mucosa of the urinary bladder may herniate through the detrusor muscle. [6] This is most often an acquired condition due to high pressure in the urinary bladder, damage, or existing connective tissue ...
In interstitial cystitis, pentosan polysulfate is believed to work by providing a protective coating to the damaged bladder wall. Pentosan polysulfate is similar in structure to the natural glycosaminoglycan coating of the inner lining of the bladder, and may replace or repair the lining, reducing its permeability.
It works by blocking receptors called alpha-1A adrenoreceptors in the prostate gland, the bladder and the urethra (the tube that leads from the bladder to the outside of the body). [5] When these receptors are activated, they cause the muscles controlling the flow of urine to contract. [ 5 ]
"The importance of regularly emptying your bladder can’t be ... of hours can result in damage to the bladder. "Overfilling can stretch the bladder muscles and potentially weaken them over time ...
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