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Reproducibility, closely related to replicability and repeatability, is a major principle underpinning the scientific method.For the findings of a study to be reproducible means that results obtained by an experiment or an observational study or in a statistical analysis of a data set should be achieved again with a high degree of reliability when the study is replicated.
An investigation of replication rates in psychology in 2012 indicated higher success rates of replication in replication studies when there was author overlap with the original authors of a study [226] (91.7% successful replication rates in studies with author overlap compared to 64.6% successful replication rates without author overlap).
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In engineering, science, and statistics, replication is the process of repeating a study or experiment under the same or similar conditions. It is a crucial step to test the original claim and confirm or reject the accuracy of results as well as for identifying and correcting the flaws in the original experiment. [1]
In semiconservative replication, when the double-stranded DNA helix is replicated, each of the two new double-stranded DNA helices consisted of one strand from the original helix and one newly synthesized. It has been called "the most beautiful experiment in biology". [1]
Replication increases the precision of an estimate, while randomization addresses the broader applicability of a sample to a population. Replication must be appropriate: replication at the experimental unit level must be considered, in addition to replication within units.
Replication of the transposable sequence starts to occur when transposase cuts single strands on opposite sides of the dsDNA. The replication is completed in the transposon complex and excised to target sequence for recombination. Transposons: These are DNA sequences that can move and replicate in different parts of a cell's genome.
Rolling circle replication (RCR) is a process of unidirectional nucleic acid replication that can rapidly synthesize multiple copies of circular molecules of DNA or RNA, such as plasmids, the genomes of bacteriophages, and the circular RNA genome of viroids. Some eukaryotic viruses also replicate their DNA or RNA via the rolling circle mechanism.