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An immature teratoma is a teratoma that contains anaplastic immature elements, and is often synonymous with malignant teratoma. [1] A teratoma is a tumor of germ cell origin, containing tissues from more than one germ cell line, [2] [3] [4] It can be ovarian or testicular in its origin. [4] and are almost always benign. [5]
Teratoma are most common germ cell tumor of ovary. Teratomas can be divided into two types: mature teratoma (benign) and immature teratoma (malignant). Immature teratomas contain immature or embryonic tissue which significantly differentiates them from mature teratomas as they carry dermoid cysts. [5]
Ovarian tumors by incidence and risk of ovarian cancer, with mature cystic teratoma at bottom and immature teratoma at right. [55] Embryonal teratomas most commonly occur in the sacrococcygeal region; sacrococcygeal teratoma is the single most common tumor found in newborn humans.
Tumor of the ovary vary remarkably as they may arise from any of the 3 cell types of the normal ovary. Ovarian tumors are classified according to the histology of the tumor, obtained in a pathology report. Histology dictates many aspects of clinical treatment, management, and prognosis. The most common forms are:
pelvis, particularly sacrococcygeal teratoma; In females, GCTs account for 30% of ovarian tumors, but only 1 to 3% of ovarian cancers in North America. In younger women, they are more common, thus in patients under the age of 21, 60% of ovarian tumors are of the germ-cell type, and up to one-third are malignant.
Sacrococcygeal teratomas are benign 75% of the time, malignant 12% of the time, and the remainder are considered "immature teratomas" that share benign and malignant features. Benign sacrococcygeal teratomas are more likely to develop in younger children who are less than 5 months old, and older children are more likely to develop malignant ...
There is no specific marker for immature teratomas, but carcinoembryonic antigen (CEA), CA-125, CA19-9, or AFP can sometimes indicate an immature teratoma. [ 32 ] Stage I teratomas make up the majority (75%) of cases and have the best prognosis, with 98% of patients surviving five years; if a Stage I tumor is also grade 1, it can be treated ...
Polyembryoma is a rare, very aggressive form of germ cell tumor usually found in the ovaries.Polyembryoma has features of both yolk sac tumour and undifferentiated teratoma/embryonal carcinoma, with a characteristic finding of embryoid bodies lying in a loose mesenchymal stroma.