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Daratumumab, sold under the brand name Darzalex among others, is an anti-cancer monoclonal antibody medication. It binds to CD38 , [ 7 ] which is overexpressed in multiple myeloma cells. [ 8 ]
It was approved for use in the United States in May 2020. [2] [7] [8]Efficacy of daratumumab and hyaluronidase-fihji (monotherapy) was evaluated in the COLUMBA trial (NCT03277105), an open-label non-inferiority trial randomizing 263 participants to daratumumab and hyaluronidase-fihj and 259 to intravenous daratumumab (daratumumab IV). [2]
Therapeutic, diagnostic and preventive monoclonal antibodies are clones of a single parent cell. When used as drugs, the International Nonproprietary Names (INNs) end in -mab.
COPENHAGEN, Denmark; October 15, 2024 – Genmab A/S (Nasdaq: GMAB) announced today that worldwide net trade sales of DARZALEX ® (daratumumab), including sales of the subcutaneous (SC) product (daratumumab and hyaluronidase-fihj, sold under the tradename DARZALEX FASPRO ® in the U.S.), as reported by Johnson & Johnson were USD 3,016 million ...
A new study by UC San Francisco found that prostate cancer cases are increasing in California, likely due to a change in screening guidelines. Experts weigh in on the threat to men's health.
January 28, 2025 at 3:10 PM Evgeniy Trofimenko // Shutterstock Medication is not always necessary or the best choice for treating a vision problem , and sometimes, medication isn't an option at all.
A man on trial for murder claims he killed a woman to protect her daughter from being sexually abused.. Zachary Hughes, a Juilliard-trained pianist, turned himself in to police in South Carolina ...
Similarly with DKRd, with the D representing Darzalex (brand name for daratumumab), and K representing Kyprolis (brand name for carfilzomib). [86] Emerging practice is not to call such drugs " chemotherapy " because they are not the traditional non-specific intracellular poisons that operate in the classic "chemo" fashion of inhibiting mitosis ...