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The application of radiation can aid the patient by providing doctors and other health care professionals with a medical diagnosis, but the exposure of the patient should be reasonably low enough to keep the statistical probability of cancers or sarcomas (stochastic effects) below an acceptable level, and to eliminate deterministic effects (e.g ...
The stomach's acidic pH and the subsequent alkalization in the intestine modifies the degree of ionization of acids and weak bases depending on a substance's pKa. [1] The pKa is the pH at which a substance is present at an equilibrium between ionized and non-ionized molecules. The Henderson–Hasselbalch equation is used to calculate pKa.
Ionization of molecules can lead to radiolysis (breaking chemical bonds), and formation of highly reactive free radicals. These free radicals may then react chemically with neighbouring materials even after the original radiation has stopped (e.g. ozone cracking of polymers by ozone formed by ionization of air). Ionizing radiation can also ...
Adiabatic ionization is a form of ionization in which an electron is removed from or added to an atom or molecule in its lowest energy state to form an ion in its lowest energy state. [16] The Townsend discharge is a good example of the creation of positive ions and free electrons due to ion impact.
Absorption is a primary focus in drug development and medicinal chemistry, since a drug must be absorbed before any medicinal effects can take place. Moreover, the drug's pharmacokinetic profile can be easily and significantly changed by adjusting factors that affect absorption.
The charge of a molecule depends upon the pH of its solution. In an acidic medium, basic drugs are more charged and acidic drugs are less charged. The converse is true in a basic medium. For example, Naproxen is a non-steroidal anti-inflammatory drug that is a weak acid (its pKa value is 5.0). The gastric juice has a pH of 2.0. It is a three ...
Also it provides a broad range sensitivity, simultaneous determination of multi-drug analytes and sufficient mass accuracy for formulation determination. [7] The DART ion source is a kind of gas-phase ionization, and it requires some sort of volatility of the analyte to support thermally assisted desorption of analyte ions. [14]
The most common health hazard of radiation is sunburn, which causes between approximately 100,000 and 1 million new skin cancers annually in the United States. [ 3 ] [ 4 ] In 2011, the World Health Organization (WHO) and the International Agency for Research on Cancer (IARC) have classified radiofrequency electromagnetic fields as possibly ...