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The Golgi apparatus (/ ˈ ɡ ɒ l dʒ i /), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. [1] Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-bound vesicles inside the cell before the vesicles are sent to their destination.
Golgin subfamily A member 4 is a protein that in humans is encoded by the GOLGA4 gene. [5] [6]The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs).
As well as the location of the cis and trans Golgi network. The cis Golgi network is the first step in the cisternal structure of a protein being packaged, while the trans Golgi network is the last step in the cisternal structure when the vesicle is being transferred to either the lysosome, the cell surface or the secretory vesicle.
A small portion of an accessory protein binds specifically to part of AP-2 complex Protein phosphorylation allows specific interactions with a clathrin adaptor protein complex. The best characterized type of vesicle is the clathrin coated vesicle (CCV). The formation of a COPII vesicle at the endoplasmic reticulum and its transport to the Golgi ...
Spindle-shaped gas vesicles in (A). Isolated cylinder-shaped gas vesicles in (B). (C) Morphogenesis of gas vesicles from a bicone to a spindle- or cylinder-shaped gas vesicle. (D) Groups of gas vesicles. They form clusters during the early stage of gas vesicle formation, and fill the cells later. (E) Detailed diagram of a gas vesicle.
2801 99412 Ensembl ENSG00000167110 ENSMUSG00000002546 UniProt Q08379 Q921M4 RefSeq (mRNA) NM_004486 NM_001366244 NM_001366246 NM_001080968 NM_133852 NM_001362695 NM_001362696 NM_001362697 NM_001362698 RefSeq (protein) NP_004477 NP_001353173 NP_001353175 NP_001074437 NP_598613 NP_001349624 NP_001349625 NP_001349626 NP_001349627 Location (UCSC) Chr 9: 128.26 – 128.28 Mb Chr 2: 32.18 – 32.2 ...
The vesicle then buds outwards and breaks free into the cytoplasm. The vesicle is moved towards its target location then docks and fuses. Once vesicles are produced in the endoplasmic reticulum and modified in the Golgi body they make their way to a variety of destinations within the cell. Vesicles first leave the Golgi body and are released ...
There are different AP complexes in mammals. AP1 is responsible for the transport of lysosomal hydrolases between the trans-Golgi network, and endosomes. [6] AP2 adaptor complex associates with the plasma membrane and is responsible for endocytosis. [7] AP3 is responsible for protein trafficking to lysosomes and other related organelles. [8]