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Antifungal resistance is a One Health concern, driven by multiple extrinsic factors, including extensive fungicidal use, overuse of clinical antifungals, environmental change and host factors. [1] Like resistance to antibacterials, antifungal resistance can be driven by antifungal use in agriculture.
Medicinal fungi are fungi that contain metabolites or can be induced to produce metabolites through biotechnology to develop prescription drugs.Compounds successfully developed into drugs or under research include those treating infection with amoeba, bacteria, fungus, virus, inhibitors of cholesterol and ergosterol synthesis, and psychotropics.
Antimicrobial use has been common practice for at least 2000 years. Ancient Egyptians and ancient Greeks used specific molds and plant extracts to treat infection. [5]In the 19th century, microbiologists such as Louis Pasteur and Jules Francois Joubert observed antagonism between some bacteria and discussed the merits of controlling these interactions in medicine. [6]
Antifungal medication, used to treat or prevent fungal infections Fungicide , an anti-fungal substance that kills fungi Fungistatics , anti-fungal substances that prevent fungi from growing or reproducing
Most antifungal drugs induce fungal cell death by destroying the cell wall of the fungus. These drugs inhibit the production of ergosterol, which is a fundamental component of the fungal cell membrane and wall. Antifungal drugs are generally classified according to their chemical structures and their corresponding mechanism of actions.
Coumarin is transformed into the natural anticoagulant dicoumarol by a number of species of fungi. [7] This occurs as the result of the production of 4-hydroxycoumarin , then further (in the presence of naturally occurring formaldehyde ) into the actual anticoagulant dicoumarol , a fermentation product and mycotoxin .
One method of research for evidence-based practice in nursing is 'qualitative research': The word implies an entity and meanings that are not experimentally examined or measured in terms of quantity, amount, frequency, or intensity. With qualitative research, researchers learn about patient experiences through discussions and interviews.
Pathogenic fungi are fungi that cause disease in humans or other organisms.Although fungi are eukaryotic, many pathogenic fungi are microorganisms. [1] Approximately 300 fungi are known to be pathogenic to humans; [2] their study is called "medical mycology".