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Etranacogene dezaparvovec, sold under the brand name Hemgenix is a gene therapy used for the treatment of hemophilia B. [5] [6] [7] Etranacogene dezaparvovec is an adeno-associated virus vector-based gene therapy which consists of a viral vector carrying a gene for clotting Factor IX. [7]
Haemophilia B, also spelled hemophilia B, is a blood clotting disorder causing easy bruising and bleeding due to an inherited mutation of the gene for factor IX, and resulting in a deficiency of factor IX. It is less common than factor VIII deficiency (haemophilia A). [3] Haemophilia B was first recognized as a distinct disease entity in 1952. [4]
In the US, fidanacogene elaparvovec is indicated for the treatment of adults with moderate to severe hemophilia B (congenital factor IX deficiency) who currently use factor IX prophylaxis therapy; or have current or historical life-threatening hemorrhage; or have repeated, serious spontaneous bleeding episodes; and do not have neutralizing antibodies to adeno-associated virus serotype Rh74var ...
It is used to treat and prevent bleeding in hemophilia B if pure factor IX is not available. [9] [11] It may also be used for reversal of warfarin therapy. [11] It is given by slow injection into a vein. [9] Another product, activated prothrombin complex concentrate or FEIBA (Factor Eight Inhibitor Bypassing Agent), may be used for acquired ...
Originating in Persia (modern-day Iran), Persians are one of the oldest and most recognizable cat breeds. They enjoy a life expectancy of 11 years. However, due to their distinct features, they ...
The study states that amongst fancy breed cats, Burmese and Birman breeds were found to have the longest life expectancy, at 14.4 years, Siamese cats on average 11.7 years, Maine Coon cats 9.7 and ...
Female cats typically outlive male cats, and crossbred cats typically outlive purebred cats. [2] [4] It has also been found that the greater a cat's weight, the lower its life expectancy on average. [4] The current oldest verified cat alive is Flossie, who was born in 1995 in the United Kingdom. [10]
Cat genetics describes the study of inheritance as it occurs in domestic cats. In feline husbandry, it can predict established traits ( phenotypes ) of the offspring of particular crosses. In medical genetics , cat models are occasionally used to discover the function of homologous human disease genes.