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Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
The drug betazole is an example of a histamine H 2 receptor agonist. ... The histamine receptor H 2 belongs to the rhodopsin-like family of G protein-coupled receptors.
The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective [1] proton pump inhibitors.
There are four main types of histamine receptors: H1, H2, H3, and H4. H1 receptors are linked to allergic responses, H2 to gastric acid regulation, H3 to neurotransmitter release modulation, and H4 to immune system function. There are four known histamine receptors: H 1 receptor – Primarily located on smooth muscle cells, endothelial cells ...
They act on H 2 histamine receptors found mainly in the parietal cells of the gastric mucosa, which are part of the endogenous signaling pathway for gastric acid secretion. Normally, histamine acts on H 2 to stimulate acid secretion; drugs that inhibit H 2 signaling thus reduce the secretion of gastric acid.
In the process, the SK&F scientists also proved the existence of histamine H 2 receptors. The SK&F team used a rational drug-design structure starting from the structure of histamine — the only design lead, since nothing was known of the then hypothetical H 2 receptor. Hundreds of modified compounds were synthesized in an effort to develop a ...
Pages in category "H2 receptor antagonists" The following 20 pages are in this category, out of 20 total. This list may not reflect recent changes. ...
Nizatidine is a histamine H 2 receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. [2] It was patented in 1980 and approved for medical use in 1988. [3] [4] It was developed by Eli Lilly.