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Epileptic seizures are a potentially serious comorbidity in people in multiple sclerosis which is uncommon but nonetheless present more often than in the general population, however there is currently a lack of evidence on the efficacy and safety of anti-epileptic medication specifically in people with multiple sclerosis.
Therefore, almost all new epilepsy drugs are initially approved only as adjunctive (add-on) therapies. Patients whose epilepsy is uncontrolled by their medication (i.e., it is refractory to treatment) are selected to see if supplementing the medication with the new drug leads to an improvement in seizure control.
Keppra (levetiracetam) – an anticonvulsant drug which is sometimes used as a mood stabilizer and has potential benefits for other psychiatric and neurologic conditions such as Tourette syndrome, anxiety disorder, and Alzheimer's disease; Klonopin – anti-anxiety and anti-epileptic medication of the benzodiazepine class
Phase I and medicaments used in animal models would make a huge list. Here only some of them with special interest are listed. GIFT15 is a treatment which suppresses the immune system, and has been successfully used in the treatment of mice. The immune system attacks the central nervous system in Multiple Sclerosis
A recent study suggests that a drug approved for the treatment of seizures may also help treat Alzheimer's in people who do not carrry the genetic mutation that predisposes them to dementia.
In the US, valproic acid is also prescribed as an anti-epileptic drug indicated for the treatment of manic episodes associated with bipolar disorder; monotherapy and adjunctive therapy of complex partial seizures and simple and complex absence seizures; adjunctive therapy in people with multiple seizure types that include absence seizures.
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