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Erythropoietin is an essential hormone for red blood cell production. Without it, definitive erythropoiesis does not take place. Under hypoxic conditions, the kidney will produce and secrete erythropoietin to increase the production of red blood cells by targeting CFU-E, proerythroblast and basophilic erythroblast subsets in the differentiation.
Erythropoiesis (from Greek 'erythro' meaning "red" and 'poiesis' "to make") is the process which produces red blood cells (erythrocytes), which is the development from erythropoietic stem cell to mature red blood cell. [1] It is stimulated by decreased O 2 in circulation, which is detected by the kidneys, which then secrete the hormone ...
Epoetin alfa, sold under the brand name Epogen among others, is a human erythropoietin produced in cell culture using recombinant DNA technology. [8] [9] Epoetin alfa is an erythropoiesis-stimulating agent. [8]
Erythropoiesis-stimulating agents (ESA) are medications which stimulate the bone marrow to make red blood cells. [1] They are used to treat anemia due to end stage kidney disease, chemotherapy, major surgery, or certain treatments in HIV/AIDS.
Erythropoietin is a sialoglycoprotein hormone produced by peritubular cells of kidney. Granulocyte -macrophage colony-stimulating factor and granulocyte CSF are given to stimulate white blood cell formation in cancer patients who are receiving chemotherapy , which tends to kill their red bone marrow cells as well as the cancer cells.
The following is a list of hormones found in Homo sapiens. Spelling is not uniform for many hormones. Spelling is not uniform for many hormones. For example, current North American and international usage uses [ citation needed ] estrogen and gonadotropin, while British usage retains the Greek digraph in oestrogen and favours the earlier ...
Peptide of Epo with amino acids 92-111 is neuroprotective while its erythropoietic potency is 10 fold less than the wild type. A short peptide sequence from the erythropoietin molecule called JM4, has been found to be non-erythropoietic yet theoretically neuroprotective and is being readied for Stage 1 and 2 clinical studies. [7] [8]
Afamelanotide, sold under the brand name Scenesse, is a medication used to prevent phototoxicity and to reduce pain from light exposure for people with erythropoietic protoporphyria. [1] [2] [4] It is a melanocortin 1 receptor (MC 1 receptor) agonist [1] and a synthetic peptide and analogue of α-melanocyte stimulating hormone. [1]