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Despite the great potential complexity and diversity of biological networks, all first-order network behavior generalizes to one of four possible input-output motifs: hyperbolic or Michaelis–Menten, ultra-sensitive, bistable, and bistable irreversible (a bistability where negative and therefore biologically impossible input is needed to return from a state of high output).
The transfer function of a two-port electronic circuit, such as an amplifier, might be a two-dimensional graph of the scalar voltage at the output as a function of the scalar voltage applied to the input; the transfer function of an electromechanical actuator might be the mechanical displacement of the movable arm as a function of electric ...
Passive diffusion across a cell membrane.. Passive transport is a type of membrane transport that does not require energy to move substances across cell membranes. [1] [2] Instead of using cellular energy, like active transport, [3] passive transport relies on the second law of thermodynamics to drive the movement of substances across cell membranes.
A simple first-order network such as a RC circuit will have a roll-off of 20 dB/decade. This is a little over 6 dB/octave and is the more usual description given for this roll-off. This can be shown to be so by considering the voltage transfer function, A, of the RC network: [1]
For a first-order process, a general transfer function is = +.Combining this with the closed-loop transfer function above returns = + + +.Simplifying this equation results in = + where = + and = +.
The bilinear transform is a first-order approximation of the natural logarithm function that is an exact mapping of the z-plane to the s-plane. When the Laplace transform is performed on a discrete-time signal (with each element of the discrete-time sequence attached to a correspondingly delayed unit impulse), the result is precisely the Z ...
The bilinear transform is a first-order Padé approximant of the natural logarithm function that is an exact mapping of the z-plane to the s-plane.When the Laplace transform is performed on a discrete-time signal (with each element of the discrete-time sequence attached to a correspondingly delayed unit impulse), the result is precisely the Z transform of the discrete-time sequence with the ...
The transfer functions (that is, how genes respond to a combination of inputs) can be assigned to each combination of promoter states as desired. In other recent work, multiscale models of gene regulatory networks have been developed that focus on synthetic biology applications.
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