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A sequela (UK: / s ɪ ˈ k w iː l ə /, [1] US: / s ɪ ˈ k w ɛ l ə /; [2] [3] usually used in the plural, sequelae /-iː /) is a pathological condition resulting from a disease, injury, therapy, or other trauma. Derived from the Latin word meaning "sequel", it is used in the medical field to mean a complication or condition following a ...
Sequelae can appear early in the development of disease or weeks to months later and are a result of the initial injury or illness. For example, a scar resulting from a burn or dysphagia resulting from a stroke would be considered sequelae. [2]
While it is commonly assumed that people either recover or die from infections, long-term symptoms—or sequelae—are a possible outcome as well. [1] Examples include long COVID (post-acute sequelae of SARS-CoV-2 infection, PASC), Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and post-Ebola virus syndrome . [ 1 ]
It is a complication (sequela) of osteomyelitis. The pathological process is as follows: infection in the bone leads to an increase in intramedullary pressure due to inflammatory exudates; the periosteum becomes stripped from the ostium, leading to vascular thrombosis; bone necrosis follows due to lack of blood supply; sequestra are formed
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Post-polio syndrome (PPS, poliomyelitis sequelae) is a group of latent symptoms of poliomyelitis (polio), occurring in more than 80% of polio infections. The symptoms are caused by the damaging effects of the viral infection on the nervous system and typically occur 15 to 30 years after an initial acute paralytic attack.
A period, often very long, of health unaffected by both the initial and the late effect conditions distinguishes a late effect from a sequela or a complication. A code for such a condition was present in the ICD-9 but is no longer present in the ICD-10. [citation needed]
Pathophysiology (or physiopathology) is a branch of study, at the intersection of pathology and physiology, concerning disordered physiological processes that cause, result from, or are otherwise associated with a disease or injury.