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Tumor cells can be hypoxic and therefore less sensitive to X-rays because most of their effects are mediated by the free radicals produced by ionizing oxygen. It has meanwhile been shown that the most sensitive cells are those that are undifferentiated , well nourished, dividing quickly and highly active metabolically .
Two main approaches to reduce radiation damage are reducing the amount of energy deposited in the sensitive material (e.g. by shielding, distance from the source, or spatial orientation), or modification of the material to be less sensitive to radiation damage (e.g. by adding antioxidants, stabilizers, or choosing a more suitable material).
The best known explanation of the oxygen effect is the oxygen fixation hypothesis developed by Alexander in 1962, [9] which posited that radiation-induced non-restorable or "fixed" nuclear DNA lesions are lethal to cells in the presence of diatomic oxygen. [10] [11] Recent hypotheses include one based on oxygen-enhanced damage from first ...
The consensus has been to assume linear no-threshold because it the simplest and most conservative of the three. Radiation hormesis is the conjecture that a low level of ionizing radiation (i.e., near the level of Earth's natural background radiation) helps "immunize" cells against DNA damage from other causes (such as free radicals or larger ...
Radiation is a moving form of energy, classified into ionizing and non-ionizing type. [4] Ionizing radiation is further categorized into electromagnetic radiation (without matter) and particulate radiation (with matter). [4] Electromagnetic radiation consists of photons, which can be thought of as energy packets, traveling in the form of a wave ...
Radioresistance is the level of ionizing radiation that organisms are able to withstand.. Ionizing-radiation-resistant organisms (IRRO) were defined as organisms for which the dose of acute ionizing radiation (IR) required to achieve 90% reduction (D10) is greater than 1,000 gray (Gy) [1]
Radiation sensitivity is the susceptibility of a material to physical or chemical changes induced by radiation. [1] Examples of radiation sensitive materials are silver chloride, photoresists and biomaterials. Pine trees are more radiation susceptible than birch due to the complexity of the pine DNA in comparison to the birch.
Tumor cells in a hypoxic environment may be as much as 2 to 3 times more resistant to radiation damage than those in a normal oxygen environment. [5] Much research has been devoted to overcoming this problem including the use of high pressure oxygen tanks, blood substitutes that carry increased oxygen, hypoxic cell radiosensitizers such as ...