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Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]
Rivaroxaban. During the SAR development of rivaroxaban, researchers realized that adding a 5-chlorothiophene-2-carboxamide group to the oxazolidonine core could increase the potency by 200 fold, which had previously been too weak for medical use. In addition to this discovery, a clear preference for the (S)-configuration was confirmed.
Antistasin, the first discovered naturally occurring direct Xa inhibitor Rivaroxaban, the first synthetic direct Xa inhibitor marketed as a drug Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood ...
Any Windows version starting from Windows 95 or later. Large File support (greater than 4 GB which requires an exFAT filesystem) for the huge wikis (English only at the time of this writing). It also works on Linux with Wine. 16 MB RAM minimum for the WikiTaxi reader, 128 MB recommended for the importer (more for speed).
At the time of launch, Microsoft deemed Windows 7 (with Service Pack 1) and Windows 8.1 users eligible to upgrade to Windows 10 free of charge, so long as the upgrade took place within one year of Windows 10's initial release date. Windows RT and the respective Enterprise editions of Windows 7, 8, and 8.1 were excluded from this offer.
Windows 10 is the last version of Microsoft Windows that supports 32-bit processors (IA-32 and ARMv7-based), the last non-IoT edition to officially lack a CPU whitelist [30] and support BIOS firmware, [31] [32] and the last version to officially support systems with TPM 1.2 or without any TPM at all.
Windows 10 version 1709: Redstone 3 October 17, 2017 1709 16299 April 9, 2019 Windows 10 version 1803: Redstone 4 April 30, 2018 1803 17134 November 12, 2019 Windows 10 version 1809: Redstone 5 November 13, 2018 1809 17763 November 10, 2020 Windows 10 version 1903: 19H1 May 21, 2019 1903 18362 December 8, 2020 Windows 10 version 1909: Vanadium
Skeletal formulae of the antibiotic linezolid (top) and the anticoagulant rivaroxaban (bottom), highlighting their similar oxazolidinone core (in blue). Created using ACD/ChemSketch 10.0 and Inkscape. Date: 11 June 2009: Source: Own work. The structural similarity between the drugs is discussed in European Medicines Agency (2008).