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Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]
Rivaroxaban. During the SAR development of rivaroxaban, researchers realized that adding a 5-chlorothiophene-2-carboxamide group to the oxazolidonine core could increase the potency by 200 fold, which had previously been too weak for medical use. In addition to this discovery, a clear preference for the (S)-configuration was confirmed.
Antistasin, the first discovered naturally occurring direct Xa inhibitor Rivaroxaban, the first synthetic direct Xa inhibitor marketed as a drug Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood ...
The most frequent adverse reactions associated with permanent drug discontinuation were bleeding events, with incidence rates of 4.3% for rivaroxaban vs. 3.1% for warfarin. [10] [9] After termination of the trial all patients received warfarin treatment. 3 to 30 days after the end of the study, risk of stroke and systematic embolism, and ...
Fondaparinux is a synthetic pentasaccharide factor Xa inhibitor. Fondaparinux binds antithrombin and accelerates its inhibition of factor Xa.. Apart from the O-methyl group at the reducing end of the molecule, the identity and sequence of the five monomeric sugar units contained in fondaparinux is identical to a sequence of five monomeric sugar units that can be isolated after either chemical ...
Medical Wikipedia is a mobile app which provides offline access to health information on Wikipedia.It is an instance of the Wikipedia arm of Kiwix.. On June 10th, 2015 Wiki Project Med Foundation and Wikimedia Switzerland launched an android app that contains all of the English Wikipedia's health care content: including medical, anatomy, medication, and sanitation related articles as tagged by ...
Start downloading a Wikipedia database dump file such as an English Wikipedia dump. It is best to use a download manager such as GetRight so you can resume downloading the file even if your computer crashes or is shut down during the download. Download XAMPPLITE from (you must get the 1.5.0 version for it to work). Make sure to pick the file ...
Andexanet alfa is a biologic agent, a recombinant modified version of human activated factor X (FXa). [17] Andexanet alfa differs from native FXa due to the removal of a 34 residue fragment that contains the Gla domain. This modification reduces andexanet alfa's anticoagulant potential.