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Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells , but also acts on haemopoietic progenitor cells and T cells .
Human hepatocyte growth factor (HGF) is an 80kD [1] pleiotropic protein that is endogenously produced by a variety of cell types from the mesenchymal cell lineage (such as cardiomyocytes and neurons). [4] It is produced and proteolytically cleaved to its active state in response to cellular injury or during apoptosis.
HgF 4 is produced by the reaction of elemental mercury with fluorine: Hg + 2 F 2 → HgF 4. HgF 4 is only stable in matrix isolation at 4 K (−269 °C); upon heating, or if the HgF 4 molecules touch each other, it decomposes to mercury(II) fluoride and fluorine: HgF 4 → HgF 2 + F 2. HgF 4 is a diamagnetic, square planar molecule.
Hepatocyte growth factor receptor (HGF receptor) [5] [6] is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. [7] The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.
These mutations produced phenotypes that were similar to phenotypes seen in TGF-β1 knockout mice. [40] Currently there are two proposed models of how αV containing integrins can activate latent TGF-β1; the first proposed model is by inducing conformational change to the latent TGF-β1 complex and hence releasing the active TGF-β1 and the ...
A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation. [1] Usually it is a secreted protein or a steroid hormone.
HGF may refer to: Harold Grinspoon Foundation, an American Jewish youth organization; Helmholtz Association of German Research Centres (German: Helmholtz-Gemeinschaft Deutscher Forschungszentren), the largest scientific organisation in Germany; Hepatocyte growth factor, a paracrine cellular growth, motility and morphogenic factor
Mercury(II) fluoride is most commonly produced by the reaction of mercury(II) oxide and hydrogen fluoride: HgO + 2 HF → HgF 2 + H 2 O. Mercury(II) fluoride can also be produced through the fluorination of mercury(II) chloride: HgCl 2 + F 2 → HgF 2 + Cl 2. or of mercury(II) oxide: [3] 2 HgO + 2 F 2 → 2 HgF 2 + O 2. with oxygen as byproduct.