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Chemical castration is castration via anaphrodisiac drugs, whether to reduce libido and sexual activity, to treat cancer, or otherwise. Unlike surgical castration , where the gonads are removed through an incision in the body, [ 1 ] chemical castration does not remove organs and is not a form of sterilization .
Castration may also refer medically to oophorectomy in female humans and animals. The term castration may also be sometimes used to refer to emasculation where both the testicles and the penis are removed together. In some cultures, and in some translations, no distinction is made between the two.
Estradiol valerate by intramuscular injection is usually used at a dosage of 10 to 20 mg every 4 weeks in the treatment of menopausal symptoms and hypoestrogenism due to hypogonadism, castration, or primary ovarian failure in women. [13] In the past, it was used at even higher doses of 10 to 40 every 1 to 4 weeks for estrogen replacement. [36]
In the modern era, removing the human penis for any such activity is very rare (with some exceptions listed below), and references to removal of the penis are almost always symbolic. Castration is less rare, and is performed as a last resort in the treatment of androgen-sensitive prostate cancer. [1] [2] [3]
Ionizing radiation may be used to treat other cancers, but this may, in some cases, induce a second form of cancer. [74] Radiation can cause cancer in most parts of the body, in all animals, and at any age, although radiation-induced solid tumors usually take 10–15 years, and can take up to 40 years, to become clinically manifest, and ...
Steroidogenesis.Trilostane inhibits 3β-HSD. Trilostane is a steroidogenesis inhibitor. [1] It is specifically an inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD). [1] [15] As a result of this action, trilostane blocks the conversion of Δ 5-3β-hydroxysteroids, including pregnenolone, 17α-hydroxypregnenolone, dehydroepiandrosterone (DHEA), and androstenediol, into Δ 4-3-ketosteroids ...
On Nov. 26, 2024, Riehle underwent a near-total glossectomy, neck dissection and tongue reconstruction. The 12-hour surgery removed 80% of her natural tongue and 75% of her lymph nodes.
[64] [8] [136] [137] [135] Aside from men with prostate cancer, liver changes have also been observed in women treated with low doses of bicalutamide (10–50 mg/day) for scalp hair loss. [138] Rates of elevated liver enzymes have ranged from 2.9 to 11.4% in these studies, which spontaneously resolved in some women and necessitated ...