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Patrick Vallance and his London co-workers first noted the interference role for asymmetric dimethylarginine in the early 1990s. [1] Today biochemical and clinical research continues into the role of ADMA in cardiovascular disease, diabetes mellitus, erectile dysfunction and certain forms of kidney disease.
L-Arginine:glycine amidinotransferase (AGAT; EC 2.1.4.1) is the enzyme that catalyses the transfer of an amidino group from L-arginine to glycine. The products are L-ornithine and glycocyamine, also known as guanidinoacetate, the immediate precursor of creatine. Creatine and its phosphorylated form play a central role in the energy metabolism ...
Nephrogenic diabetes insipidus is most common in its acquired forms, meaning that the defect was not present at birth. These acquired forms have numerous potential causes. The most obvious cause is a kidney or systemic disorder, including amyloidosis, [2] polycystic kidney disease, [3] electrolyte imbalance, [4] [5] or some other kidney defect. [2]
A 2003 study found that a combination of L-arginine and pycnogenol (a type of bark from the Pinus pinaster tree) helped men affected by ED regain normal performance over several months. L-arginine ...
The precursor compounds of L-arginine and L-citrulline can be found in foods that are high in protein (both compounds are amino acids), including beans, legumes, red meat, dairy products, fish ...
Methylated arginine is a modified version of arginine that is commonly formed from protein arginine (arginine incorporated in protein). Asymmetrically methylated forms of arginine are toxic when released during protein turnover. The protein detoxification pathway eliminates free methylated-arginine derivatives from the cell.
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