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The 5-HT 2A receptor is a subtype of the 5-HT 2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). [4] The 5-HT 2A receptor is a cell surface receptor, [5] but has several intracellular locations. [6] Like all 5-HT 2 receptors, the 5-HT 2A receptor is G q /G 11-protein coupled.
The exception to this is the 5-HT 3 receptor which is a ligand-gated ion channel. In 2014, a novel 5-HT receptor was isolated from the small white butterfly, Pieris rapae, and named pr5-HT 8. It does not occur in mammals and shares relatively low similarity to the known 5-HT receptor classes. [7]
The 5-HT 2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). [1] The 5-HT 2 subfamily consists of three G protein-coupled receptors (GPCRs) which are coupled to G q /G 11 and mediate excitatory neurotransmission , [ 2 ] including 5-HT 2A , 5-HT 2B , and 5-HT 2C .
A sensory map is an area of the brain which responds to sensory stimulation, and are spatially organized according to some feature of the sensory stimulation. In some cases the sensory map is simply a topographic representation of a sensory surface such as the skin, cochlea, or retina. In other cases it represents other stimulus properties ...
The phantom limb feeling, which is thought [3] to result from disorganization in the brain map and the inability to receive input from the targeted area, may be annoying or painful. Incidentally, it is more common after unexpected losses than planned amputations.
108068 Ensembl ENSG00000164082 ENSMUSG00000023192 UniProt Q14416 Q14BI2 RefSeq (mRNA) NM_000839 NM_001349116 NM_001349117 NM_001160353 RefSeq (protein) NP_000830 NP_001336045 NP_001336046 NP_001153825 Location (UCSC) Chr 3: 51.71 – 51.72 Mb Chr 9: 106.52 – 106.53 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in ...
The CTZ is located within the area postrema, which is on the floor of the fourth ventricle and is outside of the blood–brain barrier. [1] It is also part of the vomiting center itself. [ 2 ] The neurotransmitters implicated in the control of nausea and vomiting include acetylcholine , dopamine , histamine (H1 receptor), substance P (NK-1 ...
5-HT 2C receptors are located only within the CNS, where they can be found in several locations. The highest density of receptor expression is within the choroid plexus . Other brain locations include the nucleus of the solitary tract , dorsomedial hypothalamus , paraventricular hypothalamic nucleus and the amygdala , all of which are ...