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In toxicology, the margin of exposure (or MOE) of a substance is the ratio of its no-observed-adverse-effect level to its theoretical, predicted, or estimated dose or concentration of human intake. [1] It is used in risk assessment to determine the dangerousness of substances that are both genotoxic and carcinogenic. [2]
The REACH regulation defines them as exposure levels beneath which a substance does not harm human health. [1] According to the EU REACH legislation , manufacturers and importers of chemical substances are required to calculate DNELs as part of their chemical safety assessment (CSA) for any chemicals used in quantities of 10 tonnes or more per ...
The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose.It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect. [1]
Workplace exposure monitoring is the monitoring of substances in a workplace that are chemical or biological hazards. It is performed in the context of workplace exposure assessment and risk assessment .
The permissible exposure limit (PEL or OSHA PEL) is a legal limit in the United States for exposure of an employee to a chemical substance or physical agent such as high level noise. Permissible exposure limits were established by the Occupational Safety and Health Administration (OSHA). Most of OSHA's PELs were issued shortly after adoption of ...
Exposure analysis is the science that describes how an individual or population comes in contact with a contaminant, including quantification of the amount of contact across space and time. 'Exposure assessment' and 'exposure analysis' are often used as synonyms in many practical contexts. Risk is a function of exposure and hazard.
Acute Exposure Guideline Levels (AEGLs) set levels of chemical concentration that pose a defined level of risk to humans (the general population, including susceptible individuals). [ 1 ] [ 2 ] [ 3 ] These levels are used in preventing and responding to disasters .
An occupational exposure limit is an upper limit on the acceptable concentration of a hazardous substance in workplace air for a particular material or class of materials. It is typically set by competent national authorities and enforced by legislation to protect occupational safety and health .