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[145] [146] [147] However, a 2017 hybrid systematic review found that the incidence of depression in women treated with spironolactone for acne was less than 1%. [64] Likewise, a 10-year observational study found that the incidence of depression in 196 transgender women taking high-dose spironolactone in combination with an estrogen was less ...
A 1991 review reported that the influences of spironolactone on androgen levels in women were variable and inconsistent. [78] Spironolactone has shown no significant effect on levels of testosterone, estradiol, luteinizing hormone, and follicle-stimulating hormone in men. [146] [78]
Flibanserin [1] and Bremelanotide [3] were developed for raising sexual desire in women, whereas similar conditions in men are treated using medications for sexual dysfunction. [4] On the other hand, down-regulation on libido comes in two approaches: a direct or an indirect mechanism. Multiple drugs from each category have been proven effective ...
Spironolactone is an antimineralocorticoid (antagonist of the mineralocorticoid receptor) and potassium-sparing diuretic, ... and libido in transgender women. ...
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Side effects of spironolactone in clinical studies for acne in women Side effect RCTs Tooltip Randomized controlled trials (n (ITT Tooltip Intention-to-treat analysis) = 326) Case series (n (ITT Tooltip Intention-to-treat analysis) = 663) Number % Number % Menstrual irregularities: 38: 13.4 (of 283) 216: 33.4 (of 646) Breast tenderness: 8: 2.5: ...
For those with signs of hyperandrogenism (excessive androgen hormones) and other hormonal imbalances, spironolactone may be an effective treatment for female pattern hair loss. Spironolactone ...
It is commonly seen in women with PCOS, and also occurs in women with intersex conditions like congenital adrenal hyperplasia. [13] Hyperandrogenism is associated with virilization – that is, the development of masculine secondary sexual characteristics like male-pattern facial and body hair growth (or hirsutism), voice deepening , increased ...
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