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Earl W. McDaniel has been called the father of ion mobility mass spectrometry. [1] In the early 1960s, he coupled a low-field ion mobility drift cell to a sector mass spectrometer. [2] The combination of time-of-flight mass spectrometry and ion mobility spectrometry was pioneered in 1963 at Bell Labs. In 1963 McAfee and Edelson published an IMS ...
However, the resolving power strongly depends on the ion mobility and decreases for more mobile ions. In addition, TIMS can be capable of higher sensitivity than other ion mobility systems because no grids or shutters exist in the ion path, improving ion transmission both during ion mobility experiments and while operating in a transparent MS ...
Troubleshooting is a form of problem solving, often applied to repair failed products or processes on a machine or a system. It is a logical, systematic search for the source of a problem in order to solve it, and make the product or process operational again. Troubleshooting is needed to identify the symptoms.
The term ionometer was originally applied to a device for measuring the intensity of ionising radiation.Examples of radiation detectors described as ionometers can be found through to the 1950s but the term more often now means a device for measuring the chemical ion concentration of a fluid.
Ion chromatography (or ion-exchange chromatography) is a form of chromatography that separates ions and ionizable polar molecules based on their affinity to the ion exchanger. [1] It works on almost any kind of charged molecule —including small inorganic anions, [ 2 ] large proteins , [ 3 ] small nucleotides , [ 4 ] and amino acids .
Moisture is the main problem that affects the accuracy of ion chambers. The chamber's internal volume must be kept completely dry, and the vented type uses a desiccant to help with this. [ 2 ] Because of the very low currents generated, any stray leakage current must be kept to a minimum in order to preserve accuracy.
The most common ion gauge is the hot-cathode Bayard–Alpert gauge, with a small collector inside the grid. [1] A glass envelope with an opening to the vacuum can surround the electrodes, but usually the nude gauge is inserted in the vacuum chamber directly, the pins being fed through a ceramic plate in the wall of the chamber. Hot-cathode ...
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