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Statins appear to be effective at preventing cardiovascular disease and death in older adults, according to new research. Most clinical trials evaluating statins have not included people 75 and ...
Researchers tested simvastatin, later sold by Merck as Zocor, on 4,444 patients with high cholesterol and heart disease. After five years, the study concluded the patients saw a 35% reduction in their cholesterol, and their chances of dying of a heart attack were reduced by 42%. [12] [192] In 1995, Zocor and Mevacor both made Merck over US$1 ...
Over 45 for men and over 55 for women. Family history. Having a family history of early heart disease. Sex. People born male are at increased risk. Congenital defects. Having problems with your ...
Statins are the typically used medications, in addition to healthy lifestyle interventions. [68] Statins can reduce total cholesterol by about 50% in the majority of people, [39] and are effective in reducing the risk of cardiovascular disease in both people with [69] and without pre-existing cardiovascular disease.
A risk exists of muscle damage (myopathy and rhabdomyolysis) with statins. Hypercholesterolemia is not a risk factor for mortality in persons older than 70 years and risks from statin drugs are more increased after age 85. [2] Fibrates are indicated for hypertriglyceridemia. Fibrates typically lower triglycerides by 20% to 50%.
Over the dose range of 1 to 80 mg/day strong linear dose‐related effects were found; total cholesterol was reduced by 22.1% to 44.8%, LDL cholesterol by 31.2% to 61.2%, non-HDL cholesterol by 28.9% to 56.7% and triglycerides by 14.4% to 26.6%.
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A United States guideline recommends statins in those who have a 12% or greater risk of cardiovascular disease over the next ten years. [166] Niacin , fibrates and CETP Inhibitors , while they may increase HDL cholesterol do not affect the risk of cardiovascular disease in those who are already on statins. [ 167 ]