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Domain I (residues 1–27 and 383–414) forms a three-stranded anti-parallel β-sheet. This domain contains two disulfide bridges that are necessary for correct folding, as well as a glycosylated residue (Asn19) that is required for catalytic activity in vivo.
Glycosylation also plays a role in cell-to-cell adhesion (a mechanism employed by cells of the immune system) via sugar-binding proteins called lectins, which recognize specific carbohydrate moieties. [2] Glycosylation is an important parameter in the optimization of many glycoprotein-based drugs such as monoclonal antibodies. [6]
Proteoglycans are proteins [1] that are heavily glycosylated. The basic proteoglycan unit consists of a "core protein " with one or more covalently attached glycosaminoglycan (GAG) chain(s). [ 2 ] The point of attachment is a serine (Ser) residue to which the glycosaminoglycan is joined through a tetrasaccharide bridge (e.g. chondroitin sulfate ...
The process of glycosylation (binding a carbohydrate to a protein) is a post-translational modification, meaning it happens after the production of the protein. [3] Glycosylation is a process that roughly half of all human proteins undergo and heavily influences the properties and functions of the protein. [3]
The amino- and carboxy-terminal regions are very lightly glycosylated, but rich in cysteines. The cysteine residues participate in establishing disulfide linkages within and among mucin monomers . A large central region ("PTS domain") formed of multiple tandem repeats of 10 to 80 residue sequences in which up to half of the amino acids are ...
Glycosyl groups are exchanged during glycosylation from the glycosyl donor, the electrophile, to the glycosyl acceptor, the nucleophile. [1] The outcome of the glycosylation reaction is largely dependent on the reactivity of each partner. [2] Glycosyl also reacts with inorganic acids, such as phosphoric acid, forming an ester such as glucose 1 ...
New York. Number of Residential Swimming Pools: 503,000. Average Number of People per Pool: 38. Despite being surrounded by water, New York still has one of the highest numbers of U.S. swimming pools.
An electrically operated water pump is the prime motivator in recirculating the water from the pool. Water is forced through a filter and then returned to the pool. Using a water pump by itself is often not sufficient to completely sanitize a pool. Commercial and public pool pumps usually run 24 hours a day for the entire operating season of ...
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